The global initiative to eradicate poliomyelitis through routine vaccination has helped reduce the number of cases by more than 99% in 30 years, from an estimated 350,000 cases in 1988 to 650 reported cases in 2011. However, major epidemics are still occurring today, such as the ones in the Republic of the Congo in 2010, Tajikistan in 2010, and China in 2011. The epidemic outbreak in 2010 in the Republic of the Congo differed from the others in its exceptionally high mortality rate of 47%: out of the 445 confirmed cases, nearly 210 died. The researchers first attributed the seriousness of the epidemic to low vaccine coverage.
Newly identified mutations of the virus
In reality, the cause was something completely different. An international team including IRD researchers has just identified the virus responsible and sequenced its genetic material. The genetic sequence shows two mutations, unknown until now, of the proteins that form the “shell” (capsid) of the virus. On the face of it, this evolution complicates the task for the antibodies produced by the immune system of the vaccinated patient as they can no longer recognize the viral strain.