Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2

Fig. 1
Luminescence inhibition rate curve of the anti-(SARS-Cov-2) IgY (blue) and normal (control) IgY (red) from the pseudovirus neutralization assay. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)

Abstract

The SARS-CoV-2 virus is still spreading worldwide, and there is an urgent need to effectively prevent and control this pandemic. This study evaluated the potential efficacy of Egg Yolk Antibodies (IgY) as a neutralizing agent against the SARS-CoV-2. We investigated the neutralizing effect of anti-spike-S1 IgYs on the SARS-CoV-2 pseudovirus, as well as its inhibitory effect on the binding of the coronavirus spike protein mutants to human ACE2. Our results show that the anti-Spike-S1 IgYs showed significant neutralizing potency against SARS-CoV-2 pseudovirus, various spike protein mutants, and even SARS-CoV in vitro. It might be a feasible tool for the prevention and control of ongoing COVID-19.

Conclusion

In summary, the anti-Spike-S1 IgYs showed significant neutralizing potency against SARS-CoV-2 pseudovirus, various S mutants, and even SARS-CoV in vitro. However, the safety and efficacy of the IgYs still needs further interrogation in animal models.

At present, the SARS-CoV-2 virus is still spreading around the world, and there is much to be done to prevent and control the pandemic. The use of IgYs in aerosol or spray formulations on the respiratory tract, the oral cavity, and even the digestive tract may be a worthwhile strategy. It might prevent the invasion of the SARS-CoV-2 virus through the natural infection route. Long-term control of the SARS-CoV-2, however, will require a combination of active and passive immunization tools, drug therapy, and other preventive measures.

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Notice that this article on chicken egg yolk antibodies was published on Nov. 3, 2020. Don’t eat more chicken, eat more chicken eggs.

David DeGerolamo

      
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Kooper1
Kooper1
1 year ago

Thank you! I am presently working my way through this. So far this is great information. Once again thanks for posting the link.

Thomas Angle
Thomas Angle
1 year ago

Nice find. Thanks

Wait, does this mean all of us that have chicken are now pharmaceutical companies and should be regulated as such?

Kooper1
Kooper1
1 year ago
Reply to  Thomas Angle

I would suggest we all get immunity from prosecution! Cheers

FJQ
FJQ
1 year ago

Certainly paints the recent avian flu culling of millions of chickens in a different light.
Not to mention recent fires and other “mishaps”.

OPM
OPM
1 year ago

I can get behind this kind of inoculation:

omlet.jpg
Kooper1
Kooper1
1 year ago
Reply to  OPM

The question that needs to asked is, do you have to consume the egg yoke raw? Other than that, that looks yummy!

Thomas Angle
Thomas Angle
1 year ago
Reply to  OPM

I have no seen an omelet that big since I ordered one from the Readyville Mill In TN.

Dana
Dana
1 year ago

I’m pretty sure it would be an IgYs injection.

Dana

tom finley
tom finley
1 year ago

If you have not subscribed to Michael Yons newsletter you should, he has been on the frontlines for 2 decades.

tom finley
tom finley
1 year ago
Thomas Angle
Thomas Angle
1 year ago
Reply to  tom finley

I do think that is treason.

tom finley
tom finley
1 year ago
Reply to  Thomas Angle

Absolutely Thomas nothing less.

Thomas Angle
Thomas Angle
1 year ago
Reply to  tom finley

I think it is time that word is used by authors when it is committed.

kal
kal
1 year ago

now do you understand the fake bird flu plandemic….. using the PCR test to determine avian flu is like using the PCR test to find covid. No chickens, no chicken eggs, do ya get it now.

Donna Miller
Donna Miller
1 year ago

Eggs are the perfect building blocks… Pleasantly loving this as I love eggs anyway you fix them…